Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ala-Leu-Tyr-Leu | isozyme Ht-c | Crotalus atrox | |
Amino acid hydroxamates | isozyme Ht-c | Crotalus atrox | |
additional information | acetyl-Ala-Val-Leu-Gly-Ala, acetyl-Val-Glu-Leu-Gly-Ala, acetyl-Val-Lys-Leu-Gly-Ala, acetyl-Lys-Ala-Leu-Gly-Ala, acetyl-Val-Ala-Ile-Gly-Ala, furylacryloyl-Gly-L-Leu-NH2 | Crotalus atrox | |
phosphoramidon | i.e. N-[L-rhamnopyranosyl-oxyhydroxyphosphinyl]-L-leucyl-L-tryptophan, isozyme Ht-c | Crotalus atrox |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.023 | - |
Val-Glu-Ala-Leu-Tyr-Leu | isozyme Ht-d | Crotalus atrox | |
0.032 | - |
Leu-Val-Glu-Ala-Leu-Tyr-Leu | isozyme Ht-d | Crotalus atrox | |
0.11 | - |
Leu-Val-Glu-Ala-Leu-Tyr-Leu | isozyme Ht-c | Crotalus atrox | |
0.12 | - |
Val-Glu-Ala-Leu-Tyr-Leu | isozyme Ht-c | Crotalus atrox | |
0.14 | - |
Glu-Ala-Leu-Tyr-Leu | isozyme Ht-d | Crotalus atrox | |
0.21 | - |
acetyl-Val-Gly-Leu-Gly-Ala | isozyme Ht-c | Crotalus atrox | |
0.29 | - |
Glu-Ala-Leu-Tyr-Leu | isozyme Ht-c | Crotalus atrox | |
0.31 | - |
acetyl-Val-Ala-Leu-Gly-Gly | isozyme c, acetyl-Val-Ala-Leu-Gly-Ala, 2-aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzyl amide | Crotalus atrox | |
0.45 | - |
acetyl-Val-Ala-Leu-Gly-Gly | isozyme Ht-c | Crotalus atrox | |
0.5 | - |
acetyl-Val-Ala-Phe-Gly-Ala | isozyme Ht-c | Crotalus atrox | |
0.62 | - |
Acetyl-Val-Ala-Leu-Leu-Ala | acetyl-Val-Ala-Ala-Leu-Gly-Ala, isozyme Ht-c | Crotalus atrox | |
0.63 | - |
Acetyl-Val-Ala-Leu-Leu-Ala | isozyme Ht-d | Crotalus atrox | |
0.69 | - |
Acetyl-Val-Ala-Ala-Leu-Gly-Ala | isozyme Ht-d | Crotalus atrox | |
0.71 | - |
acetyl-Ala-Ala-Leu-Gly-Ala | - |
Crotalus atrox | |
0.76 | - |
acetyl-Glu-Ala-Leu-Gly-Ala | isozyme Ht-c | Crotalus atrox |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloproteinase | Crotalus atrox |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crotalus atrox | - |
Western diamondback rattlesnake | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Crotalus atrox | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-Aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzyl amide + H2O | - |
Crotalus atrox | ? | - |
? | |
acetyl-Ala-Ala-Leu-Gly-Ala + H2O | - |
Crotalus atrox | ? | - |
? | |
acetyl-Glu-Ala-Leu-Gly-Ala + H2O | - |
Crotalus atrox | ? | - |
? | |
Acetyl-Val-Ala-Ala-Leu-Gly-Ala + H2O | - |
Crotalus atrox | ? | - |
? | |
acetyl-Val-Ala-Leu-Gly-Gly + H2O | - |
Crotalus atrox | ? | - |
? | |
Acetyl-Val-Ala-Leu-Leu-Ala + H2O | best substrate of synthetic acetylated pentapeptides | Crotalus atrox | ? | - |
? | |
acetyl-Val-Ala-Phe-Gly-Ala + H2O | - |
Crotalus atrox | ? | - |
? | |
acetyl-Val-Gly-Leu-Gly-Ala + H2O | - |
Crotalus atrox | ? | - |
? | |
Glu-Ala-Leu-Tyr-Leu + H2O | peptide derived from insulin B-chain | Crotalus atrox | ? | - |
? | |
Leu-Val-Glu-Ala-Leu-Tyr-Leu + H2O | peptide derived from insulin B-chain, best substrate | Crotalus atrox | Leu-Val-Glu-Ala + Leu-Tyr-Leu | - |
? | |
additional information | no hydrolysis of peptide Ala-Leu-Tyr-Leu | Crotalus atrox | ? | - |
? | |
additional information | cleavage specificity, compared to hemorrhagic toxins a and b | Crotalus atrox | ? | - |
? | |
additional information | substrate requirements: small aliphatic residues at P1 (Ala or Gly) and Leu at P2 | Crotalus atrox | ? | - |
? | |
Oxidized insulin B-chain + H2O | cleavage at Gly23-Phe24 | Crotalus atrox | ? | - |
? | |
Oxidized insulin B-chain + H2O | cleavage at His5-Leu6, His10-Leu11, Ala14-Leu15 (most rapidly cleaved bond) | Crotalus atrox | ? | - |
? | |
Oxidized insulin B-chain + H2O | cleavage at Tyr16-Leu17 (slightly less rapidly cleaved bond) | Crotalus atrox | ? | - |
? | |
Val-Glu-Ala-Leu-Tyr-Leu + H2O | peptide derived from insulin B-chain | Crotalus atrox | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Crotalus atrox |